Polysaccharides are easy to achieve adjustable micropore sizes
We can deliberately adjust the internal micropore size during matrix/hydrogel preparation by changing the macroscale conditions, such as
- Changing the relative concentration of matrix components
- Introduction of spatial occupying molecules/particles that can be subsequently removed without disturbing the cage-scaffold structure of the polysaccharide.
- Change the crosslinking pattern and intensity
- Introducing the macromolecule crosslinker can shrink or expand when engaged with specific conditions/solvents.